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Rockland
MPYS Polyclonal Antibody
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Product Details
600-401-C08
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MPYS Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the c-terminus of human MPYS.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; mitochondrial mediator of IRF3 activation; MMITA; mSTING; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; Stimulator of interferon genes protein; tm173; Transmembrane protein 173
Gene Aliases: 2610307O08Rik; ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING1; TMEM173
UniProt ID: (Human) Q86WV6, (Mouse) Q3TBT3
Entrez Gene ID: (Human) 340061, (Mouse) 72512
activation of innate immune response
positive regulation of defense response to virus by host
apoptotic process
positive regulation of protein binding
regulation of type I interferon production
positive regulation of type I interferon production
interferon-beta production
positive regulation of protein import into nucleus, translocation
cellular response to interferon-beta
positive regulation of transcription factor import into nucleus
innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
cellular response to exogenous dsRNA
cellular response to organic cyclic compound
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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