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MSH3 Polyclonal Antibody
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产品信息
BS-8542R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human MSH3, amino acids 651-750.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Divergent upstream protein; DNA mismatch repair protein Msh3; DUP; epididymis secretory sperm binding protein; hMSH3; Mismatch repair protein 1; MRP1; Protein repair-1; Protein repair-3; REP-1; REP-3; unnamed protein product
基因别名: D13Em1; DUC1; DUG; DUP; FAP4; MRP1; MSH3; Rep-3; Rep3
UniProt ID: (Human) P20585, (Mouse) P13705
Entrez Gene ID: (Human) 4437, (Rat) 499505, (Mouse) 17686
nucleotide binding
DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
protein homodimerization activity
ATP-dependent DNA damage sensor activity
Y-form DNA binding
heteroduplex DNA loop binding
double-strand/single-strand DNA junction binding
molecular_function
damaged DNA binding
DNA-dependent ATPase activity
centromeric DNA binding
DNA metabolism protein
DNA repair
mismatch repair
mitotic recombination
cellular response to DNA damage stimulus
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
negative regulation of DNA recombination
meiotic mismatch repair
reciprocal meiotic recombination
biological_process
somatic hypermutation of immunoglobulin genes
positive regulation of helicase activity
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