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Invitrogen
MSH6 Recombinant Rabbit Monoclonal Antibody (M5F6)
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图: 1 / 10
MSH6 Antibody (MA572095) in IHC (P)
Immunohistochemistry analysis of MSH6 on paraffin-embedded Human Gastric Cancer tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with MSH6 Recombinant Monoclonal (Product # MA572095) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA572095
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
M5F6
抗原
KLH conjugated synthetic peptide derived from human MSH6.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G/T mismatch binding protein homolog; G/T mismatch-binding protein; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; mutS protein homolog 6; mutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; mutS-like protein 6; p160; probable G/T mismatch binding protein; homolog of bacterial MutS proteins; rCG61559-like; Sperm associated protein; sperm-associated protein; unnamed protein product
基因别名: GTBP; GTMBP; HNPCC5; HSAP; LYNCH5; MMRCS3; MSH-6; p160
UniProt ID: (Human) P52701, (Mouse) P54276
Entrez Gene ID: (Human) 2956, (Mouse) 17688, (Rat) 100360342
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
histone H3K36me3 reader activity
ATP-dependent DNA damage sensor activity
meiotic mismatch repair
DNA repair
mismatch repair
chromatin organization
spermatogenesis
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
intrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
