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OriGene
MSTN Monoclonal Antibody (OTI4F9), TrueMAB™
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MSTN Antibody (CF807789) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSTN (RC210368, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-MSTN. (1. Positive lysates LY401622 (100 µg) and LC401622 (20 µg) can be purchased separately from OriGene.
产品信息
CF807789
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
OTI4F9
抗原
Human recombinant protein fragment corresponding to amino acids 24-266 of human MSTN produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GDF-8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin
基因别名: GDF8; MSLHP; MSTN
UniProt ID: (Human) O14793
Entrez Gene ID: (Human) 2660
positive regulation of defense response to virus by host
transforming growth factor beta receptor signaling pathway
muscle organ development
response to heat
response to gravity
positive regulation of pathway-restricted SMAD protein phosphorylation
skeletal muscle atrophy
negative regulation of muscle hypertrophy
response to muscle activity
ovulation cycle process
response to testosterone
negative regulation of kinase activity
regulation of apoptotic process
skeletal muscle tissue regeneration
regulation of MAPK cascade
response to estrogen
response to ethanol
negative regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
muscle cell cellular homeostasis
cell development
negative regulation of skeletal muscle tissue growth
response to electrical stimulus
negative regulation of protein kinase B signaling
SMAD protein signal transduction
cellular response to dexamethasone stimulus
mitophagy in response to mitochondrial depolarization
xenophagy
negative regulation of skeletal muscle satellite cell proliferation
negative regulation of satellite cell differentiation
negative regulation of myoblast proliferation
