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Abnova
MTMR2 Monoclonal Antibody (4G6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00008898-M03
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4G6
抗原
MTMR2 (NP_057240, 5 a.a. approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: SSCESLGSQP AAARPPSVDS LSSASTSHSE NSVHTKSASV VSSDSISTSA DNFSPDLRVL RESNKLAEME EPPLLPGENI KDMAKDVTYI CPFTGA
靶标信息
This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphatase; phosphatidylinositol-3-phosphate phosphatase; phosphoinositide-3-phosphatase; unnamed protein product
基因别名: CMT4B; CMT4B1
UniProt ID: (Human) Q13614
Entrez Gene ID: (Human) 8898, (Rat) 315422
negative regulation of receptor internalization
dephosphorylation
negative regulation of myelination
myelin assembly
negative regulation of endocytosis
phosphatidylinositol metabolic process
phosphatidylinositol dephosphorylation
neuron development
regulation of phosphatidylinositol dephosphorylation
negative regulation of excitatory postsynaptic potential
dendritic spine maintenance
positive regulation of early endosome to late endosome transport
negative regulation of receptor catabolic process
phosphatidylinositol biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
