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Proteintech
MVP/LRP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
16478-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MVP/LRP Fusion Protein Ag9593 (544-893 aa encoded by BC015623)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.27 mg/mL
规格
40.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NWHFEVNDR KDPQETAKLF SVPDFVGDAC KAIASRVRGA VASVTFDDFH KNSARIIRTA VFGFETSEAK GPDGMALPRP RDQAVFPQNG LVVSSVDVQS VEPVDQRTRD ALQRSVQLAI EITTNSQEAA AKHEAQRLEQ EARGRLERQK ILDQSEAEKA RKELLELEAL SMAVESTGTA KAEAESRAEA ARIEGEGSVL QAKLKAQALA IETEAELQRV QKVRELELVY ARAQLELEVS KAQQLAEVEV KKFKQMTEAI GPSTIRDLAV AGPEMQVKLL QSLGLKSTLI TDGSTPINLF NTAFGLLGMG PEGQPLGRRV ASGPSPGEGI SPQSAQAPQA PGDNHVVPVL R (544-893 aa encoded by BC015623)
靶标信息
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: lrp; Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; unnamed protein product; VAULT1; vRNP
基因别名: 2310009M24Rik; LRP; MVP; VAULT1
UniProt ID: (Rat) Q62667, (Mouse) Q9EQK5
Entrez Gene ID: (Human) 9961, (Rat) 64681, (Mouse) 78388
cell proliferation
protein transport
intracellular signal transduction
ERBB signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
protein activation cascade
negative regulation of signaling
negative regulation of protein autophosphorylation
negative regulation of protein tyrosine kinase activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
