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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Myc Tag Antibodies

          OriGene

          MYC Monoclonal Antibody (OTI5E9G2), TrueMAB™

          查看其他38个Myc Tag抗体

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          Cite MYC Monoclonal Antibody (OTI5E9G2), TrueMAB™

          • 抗体检测数据 (4)
          MYC Antibody in Immunocytochemistry (ICC/IF)
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          MYC Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 4

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          MYC Antibody (CF507203) in ICC/IF

          Anti-MYC mouse monoclonal antibody (TA507203) Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MYC(RC201611). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          MYC Antibody in Immunocytochemistry (ICC/IF)
          MYC Antibody in Immunocytochemistry (ICC/IF)
          MYC Antibody in Western Blot (WB)
          MYC Antibody in Western Blot (WB)
          MYC Monoclonal Antibody (OTI5E9G2), TrueMAB™

          产品信息

          CF507203

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:200-1:4000
          -

          免疫细胞化学 (ICC/IF)

          1:100
          -
          产品规格

          种属反应

          Dog, Human, Rat

          宿主/亚型

          Mouse / IgG2a

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          OTI5E9G2

          抗原

          Full length human recombinant protein of human Myc produced in 293T
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Lyophilized

          浓度

          1 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.3, with 8% trehalose

          内含物

          no preservative

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

          靶标信息

          Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: 46-0603; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; c-myc; c-myc epitope tag; c-myc proto-oncogene; Class E basic helix-loop-helix protein 39; cmyc; Myc protein; Myc proto-oncogene protein; Myc Tag; myc-related translation/localization regulatory factor; myelocytomatosis viral oncogene homolog; Proto-oncogene c-Myc; R950-25; R95025; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog

          查看更多 收起

          基因别名: BHLHE39; C-MYC; mMyc; MRTL; MYC; MYCC; RNCMYC

          查看更多 收起

          UniProt ID: (Dog) Q28350, (Human) P01106, (Rat) P09416

          查看更多 收起

          Entrez Gene ID: (Dog) 403924, (Human) 4609, (Rat) 24577

          查看更多 收起

          功能
          RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding macromolecular complex binding protein dimerization activity E-box binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding transcription factor binding protein complex binding repressing transcription factor binding core promoter proximal region sequence-specific DNA binding double-stranded DNA binding sequence-specific DNA binding protein heterodimerization activity basic helix-loop-helix transcription factor
          参与通路
          MAPK cascade chromatin remodeling regulation of transcription, DNA-templated cellular iron ion homeostasis cellular response to DNA damage stimulus response to gamma radiation regulation of telomere maintenance negative regulation of stress-activated MAPK cascade response to drug negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation positive regulation of epithelial cell proliferation chromosome organization negative regulation of cell division regulation of somatic stem cell population maintenance positive regulation of DNA biosynthetic process positive regulation of response to DNA damage stimulus negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis positive regulation of mesenchymal cell proliferation energy reserve metabolic process transcription from RNA polymerase II promoter cell cycle arrest Notch signaling pathway positive regulation of cell proliferation regulation of gene expression oxygen transport cellular response to UV cellular response to drug fibroblast apoptotic process negative regulation of fibroblast proliferation canonical Wnt signaling pathway response to growth factor positive regulation of metanephric cap mesenchymal cell proliferation beta-catenin-TCF complex assembly in utero embryonic development B cell apoptotic process regulation of oxidative phosphorylation positive regulation of B cell apoptotic process glucose metabolic process transcription, DNA-templated DNA-templated transcription, initiation pyruvate transport amino acid transport activation of cysteine-type endopeptidase activity involved in apoptotic process inner mitochondrial membrane organization regulation of mitotic cell cycle cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage glycoprotein metabolic process response to radiation pathogenesis response to wounding flavonoid metabolic process negative regulation of gene expression positive regulation of mitochondrial membrane potential Wnt signaling pathway protein processing transformation of host cell by virus hypothalamus development negative regulation of protein binding response to estradiol skeletal muscle cell differentiation middle ear morphogenesis regulation of apoptotic process positive regulation of catalytic activity response to alkaloid pigmentation canonical Wnt signaling pathway involved in positive regulation of wound healing canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process G0 to G1 transition positive regulation of cell cycle positive regulation of glycolytic process negative regulation of glucose import lactic acid secretion skeletal system morphogenesis detection of mechanical stimulus involved in sensory perception of sound negative regulation of cell death cellular response to carbohydrate stimulus cellular response to interleukin-1 cellular response to estrogen stimulus cellular response to organic cyclic compound cellular response to hydrostatic pressure fungal-type cell wall polysaccharide metabolic process positive regulation of cellular respiration positive regulation of ATP biosynthetic process positive regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.
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