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Abnova
MYCN Polyclonal Antibody, MaxPab™
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MYCN Antibody (H00004613-D01P) in WB
Western Blot analysis of MYCN expression in transfected 293T cell line (H00004613-T01) by MYCN MaxPab polyclonal antibody.
Lane 1: MYCN transfected lysate(49.60 KDa).
Lane 2: Non-transfected lysate.
Lane 1: MYCN transfected lysate(49.60 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004613-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MYCN (NP_005369.2, 1 a.a. approximately 464 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG GLGGLTPNPV ILQDCMWSGF SAREKLERAV SEKLQHGRGP PTAGSTAQSP GAGAASPAGR GHGGAAGAGR AGAALPAELA HPAAECVDPA VVFPFPVNKR EPAPVPAAPA SAPAAGPAVA SGAGIAAPAG APGVAPPRPG GRQTSGGDHK ALSTSGEDTL SDSDDEDDEE EDEEEEIDVV TVEKRRSSSN TKAVTTFTIT VRPKNAALGP GRAQSSELIL KRCLPIHQQH NYAAPSPYVE SEDAPPQKKI KSEASPRPLK SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE LVKNEKAAKV VILKKATEYV HSLQAEEHQL LLEKEKLQAR QQQLLKKIEH ARTC
靶标信息
N-Myc protein is member of the MYC family of transcription factor proteins with a basic helix-loop-helix (bHLH) domain. N-Myc is similarly regulated and functionally complementary to C-Myc in the context of various cellular growth and differentiation processes. MYCN gene is considered the hallmark of neuroblastoma, amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHe37; Class E basic helix-loop-helix protein 37; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; oncogene pp65/67; pp65/67
基因别名: BHLHE37; MODED; MYCN; N-myc; NMYC; ODED
UniProt ID: (Human) P04198
Entrez Gene ID: (Human) 4613
cartilage condensation
positive regulation of mesenchymal cell proliferation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of cell death
lung development
embryonic digit morphogenesis
regulation of auditory receptor cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
negative regulation of astrocyte differentiation
branching morphogenesis of an epithelial tube
negative regulation of reactive oxygen species metabolic process
