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Invitrogen
MYF5 Recombinant Rabbit Monoclonal Antibody (JE38-56)
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MYF5 Antibody (MA562885) in WB
Western blot was performed using MYF5 Recombinant Rabbit Monoclonal Antibody (JE38-56) (Product # MA562885) and a 37 kDa band corresponding to MYF5 was observed across tissues tested. Whole cell extracts (30 µg lysate) of Mouse skeletal muscle (Lane 1), Mouse tonsil (Lane 2), Mouse heart (Lane 3), Rat skeletal muscle (Lane 4), Rat tonsil (Lane 5) and Rat heart (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB2300... View More
产品信息
MA562885
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE38-56
抗原
Recombinant protein within Human Myf5 aa 181-255/255.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: L6 cell lysate, mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate.
Tissue Specificity: Expressed in myotome and 86 other cell types.
Subcellular Location: Nucleus.
Sequence Similarities: 76% human.
Predicted band size: 28 kDa.
靶标信息
Myogenic factor 5 (MYF5) is a gene located on chromosome 12q21.31, encoding a basic helix-loop-helix (bHLH) transcription factor essential for skeletal muscle development and differentiation. MYF5 is one of the key members of the myogenic regulatory factor (MRF) family, which also includes MyoD, myogenin, and MRF4. It plays a crucial role in myogenesis by regulating the expression of genes necessary for muscle precursor cell proliferation and differentiation into mature muscle fibers. During embryonic development, MYF5 is involved in the formation of muscle tissue and maintenance of muscle progenitor cells. Mutations or dysregulation in MYF5 can lead to developmental abnormalities in muscle formation and are implicated in muscle-related disorders. Research into MYF5 continues to explore its regulatory mechanisms in muscle biology and potential therapeutic applications in muscular dystrophies and muscle repair processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHc2; Class C basic helix-loop-helix protein 2; Myf-5; Myogenic factor 5; myogenic regulatory factor MYF-5
基因别名: B130010J22Rik; BHLHC2; Myf-5; MYF5
UniProt ID: (Human) P13349, (Mouse) P24699
Entrez Gene ID: (Human) 4617, (Rat) 299766, (Mouse) 17877
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
protein heterodimerization activity
E-box binding
sequence-specific DNA binding
protein dimerization activity
DNA binding
basic helix-loop-helix transcription factor
cartilage condensation
ossification
somitogenesis
regulation of cell-matrix adhesion
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
muscle organ development
skeletal muscle tissue development
extracellular matrix organization
skeletal muscle cell differentiation
muscle cell fate commitment
camera-type eye development
positive regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
positive regulation of skeletal muscle fiber development
positive regulation of muscle cell differentiation
muscle tissue morphogenesis
positive regulation of myoblast fusion
muscle organ morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
cell differentiation
