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Invitrogen
Maduramicin Recombinant Mouse Monoclonal Antibody (1G6)
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Maduramicin Antibody (MA566430) in SDS-PAGE
SDS-PAGE characterization of Maduramicin under reducing conditions. Lane M: Protein marker (kDa); Lane MAD: Purified Maduramicin Recombinant Monoclonal (Product # MA566430). Maduramicin showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-431.
产品信息
MA566430
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1G6
抗原
Conjugate of MAD hapten and KLH.
偶联物
形式
Liquid
浓度
9.1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Maduramicin is a potent polyether antibiotic primarily used as an anticoccidial agent in veterinary medicine, particularly in poultry. It functions by disrupting ion transport across cell membranes, which is crucial for its efficacy against coccidia. Recent studies have explored its potential repurposing as an anticancer agent, particularly against triple-negative breast cancer (TNBC), due to its ability to inhibit calcium channel activity and alter cellular migration. The biosynthetic gene cluster responsible for maduramicin production has been identified, providing insights into its genetic and molecular structure, although genetic engineering of associated strains remains a challenge. Maduramicin's structure allows it to effectively bind and transport ions, which is central to its mechanism of action. Despite its benefits, maduramicin poses significant toxicity risks, leading to fatal poisonings in non-target species, including humans. Synonyms for maduramicin include MAD, Maduramicin Ammonium, Maduramycin, Maduramicin A, Maduramicin-alpha, Maduramicin-beta, Maduramicin-gamma, and Maduramicin-delta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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