Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Malonaldehyde Deoxyguanosine Adduct Monoclonal Antibody (4i71)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA1-25810
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4i71
抗原
Malonaldehyde deoxy guanosine adduct (M1GR).
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Protein A
保存液
PBS with 50% glycerol
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Malonaldehyde deoxyguanosine adduct (M1dG) is a significant DNA lesion formed from the reaction between malonaldehyde (MDA), a product of lipid peroxidation, and deoxyguanosine, an essential component of DNA. The predominant MDA-derived DNA adduct is 3-(2-deoxy-B-d-erythro-pentafuranosyl)pyrimido[1,2-a]purin-10(3H)-one deoxyguanosine (M1dG). This adduct is mutagenic, causing structural changes in the DNA that can lead to mutations. M1dG has been detected and quantified in human tissues using sensitive techniques such as liquid chromatography-nanoelectrospray ionization-high-resolution tandem mass spectrometry (LC-NSI-HRMS/MS). The presence of M1dG is noteworthy because it serves as a biomarker for oxidative stress and has implications in cancer and other diseases. Studies have demonstrated that the formation of M1dG is comparable to DNA adducts from exogenous carcinogens, making it an important target for research in lifestyle and diet-related cancer risk assessments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
