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Invitrogen
MyD88 Polyclonal Antibody
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MyD88 Antibody (PA5-19919) in ICC/IF
Immunofluorescence analysis of MyD88 was performed using 70% confluent log phase SK-BR-3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with MyD88 Polyclonal Antibody (Product # PA5-19919) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 (Product # A27034)... View More
产品信息
PA5-19919
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to 17 amino acids near carboxy terminus of human MYD88 isoform 1. The immunogen is located within the last 50 amino acids of MYD88.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Suggested positive controls are A431, A549, K562, HepG2, or NIH/3T3 Cell Lysates.
PA5-19919 can be used with blocking peptide PEP-0045.
Predicted molecular ~ 35kD. In Western blot applications, this antibody has been observed to detect a band at: 35kD
Predicted species reactivity based on immunogen sequence: Pig: (94%), Sheep: (82%), Bovine: (82%), Chicken: (82%)
Antibodies should not be exposed to prolonged high temperatures.
靶标信息
Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: mutant myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response gene 88; Myeloid differentiation primary response protein MyD88
基因别名: MYD88; MYD88D
UniProt ID: (Human) Q99836, (Rat) Q6Y1S1, (Mouse) P22366
Entrez Gene ID: (Human) 4615, (Rat) 301059, (Mouse) 17874
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
apoptotic process
inflammatory response
signal transduction
cell surface receptor signaling pathway
positive regulation of type I interferon production
positive regulation of interleukin-17 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
toll-like receptor 9 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
response to interleukin-1
3'-UTR-mediated mRNA stabilization
cellular response to mechanical stimulus
response to molecule of fungal origin
JNK cascade
Toll signaling pathway
response to virus
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
response to peptidoglycan
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
regulation of cell proliferation
negative regulation of growth of symbiont in host
positive regulation of chemokine biosynthetic process
type I interferon biosynthetic process
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
establishment of endothelial intestinal barrier
immune system process
immune response
transmembrane receptor protein serine/threonine kinase signaling pathway
