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Invitrogen
NAIP Polyclonal Antibody
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产品信息
PA5150104
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Neuronal Apoptosis Inhibitory Protein (NAIP) (Leu500-Glu759)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: baculoviral IAP repeat-containing 1a; Baculoviral IAP repeat-containing protein 1a; FLJ18088; FLJ42520; FLJ58811; Neuronal apoptosis inhibitory protein 1
基因别名: AV364616; Birc1a; D13Lsd1; Naip; Naip-rs1; Naip1
UniProt ID: (Mouse) Q9QWK5
Entrez Gene ID: (Mouse) 17940
apoptotic process
regulation of signal transduction
negative regulation of peptidase activity
protein ubiquitination
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to estrogen stimulus
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
