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Proteintech
NBL1 Polyclonal Antibody
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产品信息
12069-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NBL1 Fusion Protein Ag2706 (24-180 aa encoded by BC012037)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The MW of this protein is 19 kDa, and this antibody specifically recognizes the 19 kDa protein.
Immunogen sequence: LALFPDKSA WCEAKNITQI VGHSGCEAKS IQNRACLGQC FSYSVPNTFP QSTESLVHCD SCMPAQSMWE IVTLECPGHE EVPRVDKLVE KILHCSCQAC GKEPSHEGLS VYVQGEDGPG SQPGTHPHPH PHPHPGGQTP EPEDPPGAPH TEEEGAED (24-180 aa encoded by BC012037 )
靶标信息
This gene product is the founding member of the evolutionarily conserved CAN family of proteins, which contain a domain resembling the CTCK motif found in a number of signaling molecules. These proteins are secreted, and act as BMP antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; N03; neuroblastoma candidate region, suppression of tumorigenicity 1; Neuroblastoma suppressor of tumorigenicity 1; Neuroblastoma, suppression of tumorigenicity 1 (DNA segment human D1S1733E); Protein N03; Zinc finger protein DAN
基因别名: D1S1733E; D4H1S1733E; DAN; Dana; DAND1; NB; NBL1; NO3
UniProt ID: (Human) P41271, (Mouse) Q61477, (Rat) Q06880
Entrez Gene ID: (Human) 4681, (Mouse) 17965, (Rat) 50594
nervous system development
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of BMP from receptor via BMP binding
positive regulation of neuron differentiation
determination of dorsal identity
neuron projection morphogenesis
negative regulation of monocyte chemotaxis
