Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
NCF4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
14648-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NCF4 Fusion Protein Ag6241 (1-348 aa encoded by BC002798)
偶联物
形式
Liquid
浓度
0.17 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Product # 14648-1-AP is a rabbit polyclonal antibody raised against the full-length of human NCF4.The MW of this protein is 40 kDa, and this antibody specifically recognizes the 40 kDa protein.
Immunogen sequence: MAVAQQLRA ESDFEQLPDD VAISANIADI EEKRGFTSHF VFVIEVKTKG GSKYLIYRRY RQFHALQSKL EERFGPDSKS SALACTLPTL PAKVYVGVKQ EIAEMRIPAL NAYMKSLLSL PVWVLMDEDV RIFFYQSPYD SEQVPQALRR LRPRTRKVKS VSPQGNSVDR MAAPRAEALF DFTGNSKLEL NFKAGDVIFL LSRINKDWLE GTVRGATGIF PLSFVKILKD FPEEDDPTNW LRCYYYEDTI STIKSVAWEG GACPAFLPSL RPPPLTSPSH GSLSHSKAPS GSQMSHNAVT SHQRPGWPGQ PHSPFPHPTP HFQPDASLLQ PVTPLGTSRW RKISAALPY (1-348 aa encoded by BC002798 )
靶标信息
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CTA-833B7.1; MGC3810; NCF-4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; OTTHUMP00000028736; OTTHUMP00000043756; p40-phox; p40phox; SH3 and PX domain-containing protein 4
基因别名: AI451400; CGD3; NCF; NCF4; P40PHOX; SH3PXD4
UniProt ID: (Human) Q15080, (Mouse) P97369
Entrez Gene ID: (Human) 4689, (Rat) 500904, (Mouse) 17972
