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Proteintech
NCK1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
15247-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NCK1 Fusion Protein Ag0979 (84-377 aa encoded by BC006403)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.21 mg/mL
规格
31.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: PSVPDSASP ADDSFVDPGE RLYDLNMPAY VKFNYMAERE DELSLIKGTK VIVMEKCSDG WWRGSYNGQV GWFPSNYVTE EGDSPLGDHV GSLSEKLAAV VNNLNTGQVL HVVQALYPFS SSNDEELNFE KGDVMDVIEK PENDPEWWKC RKINGMVGLV PKNYVTVMQN NPLTSGLEPS PPQCDYIRPS LTGKFAGNPW YYGKVTRHQA EMALNERGHE GDFLIRDSES SPNDFSVSLK AQGKNKHFKV QLKETVYCIG QRKFSTMEEL VEHYKKAPIF TSEQGEKLYL VKHLS (84-377 aa encoded by B C006403)
靶标信息
NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK adapter protein 1; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; non-catalytic region of tyrosine kinase; non-catalytic region of tyrosine kinase adaptor protein 1; SH2/SH3 adapter protein NCK-alpha; SH2/SH3 adapter protein NCK1; SH2/SH3 adaptor protein NCK-alpha; unnamed protein product
基因别名: 6330586M15Rik; D230010O13Rik; NCK; Nck-1; NCK1; NCKalpha
UniProt ID: (Mouse) Q99M51
Entrez Gene ID: (Human) 4690, (Rat) 300955, (Mouse) 17973
protein kinase inhibitor activity
receptor binding
protein binding
cytoskeletal adaptor activity
protein domain specific binding
receptor signaling complex scaffold activity
protein binding, bridging
receptor tyrosine kinase binding
signaling adaptor activity
cadherin binding
ephrin receptor binding
eukaryotic initiation factor eIF2 binding
protein sequestering activity
molecular condensate scaffold activity
protein kinase regulator activity
scaffold/adaptor protein
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
signal complex assembly
cell migration
positive regulation of actin filament polymerization
response to endoplasmic reticulum stress
regulation of translation initiation in response to endoplasmic reticulum stress
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin receptor signaling pathway
ephrin receptor signaling pathway
negative regulation of T cell receptor signaling pathway
antiviral innate immune response
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of cap-dependent translational initiation
positive regulation of cap-independent translational initiation
negative regulation of PERK-mediated unfolded protein response
negative regulation of protein kinase activity
substrate-dependent cell migration, cell extension
actin filament organization
lamellipodium assembly
positive regulation of translation in response to stress
negative regulation of peptidyl-serine phosphorylation
response to other organism
negative regulation of cell death
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
peptidyl-serine dephosphorylation
negative regulation of endoplasmic reticulum unfolded protein response
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
regulation of translation
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
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