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Invitrogen
NCOA2 Polyclonal Antibody
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产品信息
PA1-32281
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Rabbits were immunized with a synthetic peptide, which represented a portion of human Nuclear Recptor Coactivator 2 encoded within exon 9 (LocusLink ID 10499). Antibodies were affinity purified using the peptide immobilized on solid support.
偶联物
形式
Liquid
保存条件
4°C
运输条件
Wet ice
产品详细信息
PA1-32281 detects NCOA2 from human samples.
PA1-32281 has been successfully used in immunoprecipitation, Western blot applications.
The PA1-32281 immunogen is: Rabbits were immunized with a synthetic peptide, which represented a portion of human Nuclear Recptor Coactivator 2 encoded within exon 9 (LocusLink ID 10499). Antibodies were affinity purified using the peptide immobilized on
靶标信息
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator2, NCOA2 or TIF2, aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors, are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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