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Alomone Labs, LTD
NCX2 (SLC8A2) Polyclonal Antibody
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NCX2 (SLC8A2) Antibody (ANX-012-200UL) in IHC (F)
Expression of NCX2 in rat cerebellum - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-NCX2 (SLC8A2) Antibody (#ANX-012), (1:100). A. NCX2 staining (red) is expressed in the molecular layer (M) and Purkinje cells (arrows). B. DAPI counterstain (blue) displays the layout of cerebellar layers. C. Merge of A and B demonstrates restriction of NCX2 expression t... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ANX-012-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RVGDAQGMFEPDGG, corresponding to amino acid residues 486-499 of rat NCX2, 3rd intracellular loop
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
规格
160 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+-exchanging protein Nac2; solute carrier family 8 (sodium/calcium exchanger), member 2; solute carrier family 8 member 2; unnamed protein product
基因别名: NCX2
UniProt ID: (Human) Q9UPR5, (Rat) P48768, (Mouse) Q8K596
Entrez Gene ID: (Human) 6543, (Rat) 140447, (Mouse) 110891
response to ischemia
ion transport
calcium ion transport
cellular calcium ion homeostasis
cell communication
learning or memory
learning
memory
regulation of gene expression
sodium ion transmembrane transport
regulation of short-term neuronal synaptic plasticity
synapse organization
cognition
regulation of cytosolic calcium ion concentration
transmembrane transport
long-term synaptic potentiation
neuron cellular homeostasis
calcium ion transmembrane transport
modulation of excitatory postsynaptic potential
regulation of postsynaptic cytosolic calcium ion concentration
regulation of action potential firing pattern
regulation of calcineurin-mediated signaling
transport across blood-brain barrier
positive regulation of intracellular signal transduction
regulation of cardiac conduction
calcium ion export from cell
sodium ion transport
telencephalon development
response to vitamin D
calcium ion transport into cytosol
calcium ion import across plasma membrane
regulation of system process
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