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Invitrogen
NDUFAF2 Polyclonal Antibody
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NDUFAF2 Antibody (PA5-48555) in IHC (P)
Immunohistochemical analysis of NDUFAF2 in formalin fixed and paraffin embedded human skeletal muscle tissue. Samples were probed with a NDUFAF2 Antibody (Center) (Product # PA5-48555) followed by peroxidase conjugation of the secondary antibody and DAB staining.
产品信息
PA5-48555
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 71-99 amino acids from the Central region of human NDUFAF2.
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
靶标信息
Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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