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Invitrogen
NEIL2 Polyclonal Antibody
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产品信息
PA5-66685
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human NEIL2
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: IHPLSLGSVLS ASRREVLVDH VVEFSTAWLQ GKFQGRPQHT QVYQKEQCPA GHQVMKEAFG PEDGLQRLTW WCPQCQPQLS EEPEQCQFS
Highest antigen sequence identity to the following orthologs - mouse 74%, rat 76%.
靶标信息
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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