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Proteintech
NELF-A Polyclonal Antibody
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产品信息
10456-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NELF-A Fusion Protein Ag0708 (6-314 aa encoded by BC002764)
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ESDTGLWLH NKLGATDELW APPSIASLLT AAVIDNIRLC FHGLSSAVKL KLLLGTLHLP RRTVDEMKGA LMEIIQLASL DSDPWVLMVA DILKSFPDTG SLNLELEEQN PNVQDILGEL REKVGECEAS AMLPLECQYL NKNALTTLAG PLTPPVKHFQ LKRKPKSATL RAELLQKSTE TAQQLKRSAG VPFHAKGRGL LRKMDTTTPL KGIPKQAPFR SPTAPSVFSP TGNRTPIPPS RTLLRKERGV KLLDISELDM VGAGREAKRR RKTLDAEVVE KPAKEETVVE NATPDYAAGL VSTQKLGSLN (6-314 aa encoded by BC002764)
靶标信息
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ10442; FLJ25112; mWHSC2; Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 homolog; Wolf-Hirschhorn syndrome candidate 2 protein
基因别名: NELF-A; NELFA; P/OKcl.15; WHSC2; Whsc2h
UniProt ID: (Human) Q9H3P2, (Mouse) Q8BG30
Entrez Gene ID: (Human) 7469, (Mouse) 24116
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of transcription elongation from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of histone H3-K4 methylation
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
multicellular organism development
positive regulation of viral transcription
