OriGene

NF Monoclonal Antibody (OTI3F7), TrueMAB™

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

CF190077

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化（石蜡） (IHC (P))

1:2,000
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OTI3F7

抗原

Synthetic peptide corresponding to the conserved region of human neurofilament heavy polypeptide (NEFH), medium polypeptide (NEFM) and light polypeptide (NF68, NEFL)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 8% trehalose

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Synthetic peptide sequence is EYQDLLNVKMALDIEIAAYRKLLEGEE

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

靶标信息

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Diseases associated with NEFM include Pineal Parenchymal Tumor Of Intermediate Differentiation and Wallerian Degeneration. Among its related pathways are Amyotrophic lateral sclerosis (ALS) and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 160 kDa neurofilament protein; 200 kDa neurofilament protein; 68 kDa neurofilament protein; light molecular weight neurofilament protein; NEFH/NEFM/NEFL; neurofilament; Neurofilament 3; neurofilament heavy; Neurofilament heavy polypeptide; neurofilament light; Neurofilament light polypeptide; Neurofilament medium polypeptide; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet H protein; Neurofilament triplet L protein; Neurofilament triplet M protein; neurofilament, heavy polypeptide 200kDa; neurofilament, light polypeptide 68kDa; neurofilament, medium polypeptide 150kDa; neurofilament-3; neurofilament-3 (150 kD medium); neurofilament-l; NF-H; NF-L; NF-M; NHC; NLC; protein phosphatase 1, regulatory subunit 110

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基因别名: CMT1F; CMT2CC; CMT2E; KIAA0845; NEF3; NEFH; NEFL; NEFM; NF-L; NF-M; NF68; NFH; NFL; NFM; PPP1R110

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UniProt ID: (Human) P12036, (Human) P07196, (Human) P07197

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Entrez Gene ID: (Human) 4744, (Human) 4747, (Human) 4741

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功能
structural molecule activity structural constituent of cytoskeleton microtubule binding toxic substance binding kinesin binding protein kinase binding protein binding, bridging dynein binding protein heterodimerization activity Ras guanyl-nucleotide exchange factor activity protein binding protein C-terminus binding protein domain specific binding identical protein binding phospholipase binding
参与通路
MAPK cascade microtubule cytoskeleton organization anterograde axonal transport retrograde axonal transport response to toxic substance peripheral nervous system axon regeneration axonal transport of mitochondrion spinal cord development hippocampus development cerebral cortex development regulation of axon diameter neurofilament bundle assembly locomotion response to peptide hormone negative regulation of neuron apoptotic process positive regulation of GTPase activity intermediate filament polymerization or depolymerization intermediate filament organization neuron projection morphogenesis positive regulation of axonogenesis neuromuscular process controlling balance protein polymerization response to corticosterone response to sodium arsenite response to acrylamide ovarian follicle atresia axonogenesis cell projection assembly axon regeneration cellular response to oxidative stress response to cocaine peripheral nervous system neuron axonogenesis axon development cellular response to estradiol stimulus regulation of organelle transport along microtubule mitophagy in response to mitochondrial depolarization
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