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Invitrogen
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PA1-33149 detects NF1 from human samples.
PA1-33149 has been successfully used in immunoprecipitation, Western blot applications.
The PA1-33149 immunogen is: Synthetic peptide corresponding to a region within the C-terminus of human NF1.
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
仅用于科研。不用于诊断过程。未经明确授权不得转售。