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Invitrogen
NFIA Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-52252
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LKSVEDEMDS PGEEPFYTGQ GRSPGSGSQS SGWHEVEPGM PSPTTLKKSE KSGFSSPSPS QTSSLGTAFT QHHRPVITGP RASPHATPST LHFPTSPIIQ Q
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 100%.
靶标信息
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CCAAT-box-binding transcription factor; CTF; DNA-binding transcription factor; DNA-binding, transcription factor; NF-I/A; NF1-A; NFI-A; NFI-A-short; NfiA; NfiA splice variant; nuclear factor 1/A; TGGCA-binding protein; unnamed protein product
基因别名: 1110047K16Rik; 9430022M17Rik; BRMUTD; C1DELp32p31; CTF; DEL1P32P31; NF-I/A; NF1-A; NF1A; NFI-A; NFI-L
UniProt ID: (Human) Q12857, (Mouse) Q02780, (Rat) P09414
Entrez Gene ID: (Human) 4774, (Mouse) 18027, (Rat) 25492
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
DNA-binding transcription factor binding
cell morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to wounding
exit from mitosis
gene expression
glial cell proliferation
glial cell fate specification
neurogenesis
BMP signaling pathway
limb morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neuron fate specification
generation of neurons
cartilage development
retina development in camera-type eye
synapse maturation
neural precursor cell proliferation
ureter development
response to Aroclor 1254
viral genome replication
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