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Bioss

NFIB/NF1B2 Polyclonal Antibody

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产品信息

BS-11899R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-

流式细胞分析 (Flow)

1:20-1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human NFIB/NF1B2, amino acids 1-100.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

NFIB (Nuclear Factor I B) is a member of the Nuclear Factor I (NFI) family of transcription factors that play critical roles in DNA replication and gene regulation. NFIB is widely involved in developmental processes, including lung and brain maturation, and has been implicated in tumorigenesis, where altered expression or rearrangements can influence cell proliferation, differentiation, and metastatic potential. NF1B2, a related isoform/variant within the NFI family context, contributes to the fine-tuning of transcriptional regulation through differential expression and functional modulation. Together, NFIB and NF1B2 are important regulators of gene networks governing cellular development, tissue-specific differentiation, and disease-associated pathways, making them significant targets for both basic biological research and translational studies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; Nuclear factor 1 B-type; nuclear factor 1/B; Nuclear factor I/B; olfactory epithelium nuclear factor I-B; TGGCA-binding protein; transcription factor; unnamed protein product

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基因别名: 6720429L07Rik; CTF; E030026I10Rik; HMGIC/NFIB; MACID; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB; NFIB2; NFIB3

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UniProt ID: (Human) O00712, (Mouse) P97863

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Entrez Gene ID: (Human) 4781, (Mouse) 18028, (Rat) 29227

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription corepressor activity DNA-binding transcription factor gene-specific transcriptional regulator
参与通路
negative regulation of transcription from RNA polymerase II promoter tissue homeostasis chondrocyte differentiation glandular epithelial cell differentiation DNA replication regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter brain development cell proliferation response to wounding response to bacterium glial cell differentiation exit from mitosis gene expression glial cell proliferation stem cell population maintenance principal sensory nucleus of trigeminal nerve development glial cell fate specification cell proliferation in forebrain anterior commissure morphogenesis neurogenesis lung development forebrain development hindbrain development regeneration negative regulation of DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter neuron fate specification generation of neurons retina development in camera-type eye Clara cell differentiation Type I pneumocyte differentiation Type II pneumocyte differentiation salivary gland cavitation cell differentiation involved in salivary gland development lung ciliated cell differentiation neural precursor cell proliferation commissural neuron axon guidance stem cell proliferation negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of stem cell proliferation negative regulation of mesenchymal cell proliferation involved in lung development negative regulation of epithelial cell proliferation involved in lung morphogenesis transcription, DNA-templated transcription from RNA polymerase II promoter negative regulation of cell proliferation sensory perception of smell negative regulation of transcription, DNA-templated
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