Proteintech

NFKB1 p105/p50 Polyclonal Antibody

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NFKB1 p105/p50 Polyclonal Antibody

产品信息

14220-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
查看129篇已发表文章 129篇已发表文章

免疫组化 (IHC)

Assay-dependent
查看12篇已发表文章 12篇已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:500
查看19篇已发表文章 19篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
查看3篇已发表文章 3篇已发表文章

染色质免疫沉淀 实验 (ChIP)

-
查看1篇已发表文章 1篇已发表文章

RNA免疫共沉淀 (RIP)

-
查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

-
查看4篇已发表文章 4篇已发表文章

不适用 (N/A)

-
查看6篇已发表文章 6篇已发表文章
产品规格

种属反应

Human, Rat

已发表种属

Chicken, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

NF-kappaB Fusion Protein Ag5458 (1-368 aa encoded by BC051765)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody can bind both p105 and p50 isoforms of NFKB1.

Immunogen sequence: MAEDDPYLG RPEQMFHLDP SLTHTIFNPE VFQPQMALPT ADGPYLQILE QPKQRGFRFR YVCEGPSHGG LPGASSEKNK KSYPQVKICN YVGPAKVIVQ LVTNGKNIHL HAHSLVGKHC EDGICTVTAG PKDMVVGFAN LGILHVTKKK VFETLEARMT EACIRGYNPG LLVHPDLAYL QAEGGGDRQL GDREKELIRQ AALQQTKEMD LSVVRLMFTA FLPDSTGSFT RRLEPVVSDA IYDSKAPNAS NLKIVRMDRT AGCVTGGEEI YLLCDKVQKD DIQIRFYEEE ENGGVWEGFG DFSPTDVHRQ FAIVFKTPKY KDINITKPAS VFVQLRRKSD LETSEPKPFL YYPEIKDKEE VQRKRQKLM (1-368 aa encoded by BC051765 )

靶标信息

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: DKFZp686C01211; DNA-binding factor KBF1; EBP-1; MGC54151; NF KB; NF-kappabeta; NF-kB p50/p105; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105

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基因别名: CVID12; EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1; p105; p50

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UniProt ID: (Human) P19838

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Entrez Gene ID: (Human) 4790, (Rat) 81736

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功能
regulatory region DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding heat shock protein binding identical protein binding protein homodimerization activity actinin binding transcription regulatory region DNA binding protein heterodimerization activity RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding double-stranded DNA binding sequence-specific DNA binding Rel homology transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter stimulatory C-type lectin receptor signaling pathway transcription from RNA polymerase II promoter apoptotic process inflammatory response response to oxidative stress I-kappaB kinase/NF-kappaB signaling positive regulation of macrophage derived foam cell differentiation positive regulation of lipid storage negative regulation of calcidiol 1-monooxygenase activity negative regulation of vitamin D biosynthetic process membrane protein intracellular domain proteolysis negative regulation of cellular protein metabolic process negative regulation of cholesterol transport positive regulation of type I interferon production response to muscle stretch NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway negative regulation of apoptotic process negative regulation of interleukin-12 biosynthetic process innate immune response positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to copper ion negative regulation of inflammatory response T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to nicotine cellular response to carbohydrate stimulus cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to dsRNA cellular response to peptide hormone stimulus positive regulation of canonical Wnt signaling pathway positive regulation of hyaluronan biosynthetic process cellular response to diterpene cellular response to glucoside cellular response to brain-derived neurotrophic factor stimulus positive regulation of miRNA metabolic process negative regulation of cytokine production regulation of transcription, DNA-templated signal transduction response to bacterium response to cytokine negative regulation of transcription, DNA-templated
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