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Invitrogen
NFX1 Polyclonal Antibody
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产品信息
PA5-67299
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SSPPPCHLSRQ VPYDEISAVH QHSYHPSGSK PKSQQTSFQS SPCNKSPKSH GLQNQPWQKL RNEKHHIRVK KAQSLAEQTS DTA
Highest antigen sequence identity to the following orthologs - mouse 74%, rat 74%.
靶标信息
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp779G2416; MGC20369; Nuclear transcription factor, X box-binding protein 1; Transcriptional repressor NF-X1; X-box binding 1
基因别名: NFX1; NFX2; TEG-42; Tex42
UniProt ID: (Human) Q12986
Entrez Gene ID: (Human) 4799
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
ligase activity
poly(A) RNA binding
zinc finger transcription factor
