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Invitrogen
NGEF Polyclonal Antibody
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NGEF Antibody (PA5-143696) in ICC/IF
Immunocytochemistry analysis of NGEF in pervanadate-treated mouse C2C12. The cells were labeled with rabbit NGEF polyclonal antibody (Product # PA5-143696) and a Ephexin-1 (Tyr-87) antibody, then the antibodies were detected using appropriate secondary antibodies conjugated to Cy3.
产品信息
PA5-143696
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Ephexin-1 synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminal region of mouse ephexin-1. This sequence has significant homology to the same region in human and rat ephexin-1, and has low homology to other known proteins.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects an 80 kDa* band corresponding to ephexin-1 in Western blots of human A431, Jurkat, and HUVEC cells, as well as rat PC12 cells and mouse brain tissue.
靶标信息
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain-enriched SH3-domain protein Besh3; Eph-interacting exchange protein; Ephexin-1; Neuronal guanine nucleotide exchange factor; transforming immortalised mammary epithelial sequence 2
基因别名: ARHGEF27; Besh3; EPHEXIN; NGEF; Tims2
UniProt ID: (Human) Q8N5V2, (Mouse) Q8CHT1
Entrez Gene ID: (Human) 25791, (Mouse) 53972, (Rat) 246217
regulation of Rho protein signal transduction
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
ephrin receptor signaling pathway
regulation of small GTPase mediated signal transduction
negative regulation of dendritic spine morphogenesis
multicellular organism development
nervous system development
cellular process
cell differentiation
