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Invitrogen
NGFR Monoclonal Antibody (ME20.4)
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NGFR Antibody (MA1-20167) in ICC/IF
Stem cells international 2012 -
Figure 5 Confocal photographs showing that BM-MNCs cultured in neurobasal media supplemented with NRG1-III express the p75(NGF) receptor. The addition of 10 nM NRG1-III for 48-hrs to 6-day-old cultures increased the expression of p75(NGF) (b) over untreated control cells (a); (c, d) are control cultures stained with only the secondary antibody. The nuclei (blue) were stained with DAPI.
产品信息
MA1-20167
应用
建议稀释比
已发表文章
产品规格
种属反应
Cat,
Human,
Non-human primate,
Pig
已发表种属
Human,
Pig
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
ME20.4
抗原
Human melanoma cell line WM245.
偶联物
形式
Liquid
浓度
2.8 mg/mL
保存液
Ascites
内含物
15mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: human tongue.
This antibody does not cross-react with mouse, rat, or chicken p75 NGF receptors.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16
基因别名: CD271; Gp80-LNGFR; NGFR; NGR; p75(NTR); p75NTR; TNFRSF16
UniProt ID: (Human) P08138
Entrez Gene ID: (Pig) 100525607, (Human) 4804
beta-amyloid binding
signal transducer activity
receptor activity
transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity
neurotrophin TRKA receptor binding
protein binding
Rab GTPase binding
ubiquitin protein ligase binding
nerve growth factor binding
preprotein binding
transmembrane signal receptor
intracellular protein transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
axon guidance
response to wounding
negative regulation of neuron projection development
sensory perception of pain
membrane protein intracellular domain proteolysis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
regulation of cell proliferation
glucose homeostasis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
negative regulation of axonogenesis
positive regulation of axonogenesis
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
apoptotic signaling pathway
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
regulation of glucose import in response to insulin stimulus
