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Alomone Labs, LTD
NGL-2/LRRC4 (extracellular) Polyclonal Antibody
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NGL-2/LRRC4 (extracellular) Antibody (ANR-162-200UL) in IHC (F)
Expression of NGL-2/LRRC4 in rat hypothalamus. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-NGL-2/LRRC4 (extracellular) Antibody (#ANR-162), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. NGL-2/LRRC4 immunoreactivity (green) appears in neurons (arrows). B. Pre-incubation of the Antibody with NGL-2/LRRC4 (extracellular) Blocking Peptide (BLP-NR162), suppressed... View More
产品信息
ANR-162-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)STDTTDKMQTSLDE, corresponding to amino acid residues 507-520 of mouse LRRC4, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; Leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4-like protein; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2; NLG2; protein NGL-2
基因别名: BAG; LRRC4; MBAG1; NAG14; NGL-2; NLG-2; UNQ554/PRO1111
UniProt ID: (Human) Q9HBW1, (Mouse) Q99PH1, (Rat) Q45R42
Entrez Gene ID: (Human) 64101, (Mouse) 192198, (Rat) 641521
