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Alomone Labs, LTD

NHERF-1/EBP50 Polyclonal Antibody

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NHERF-1/EBP50 Polyclonal Antibody

产品信息

APZ-006-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-
产品规格

种属反应

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)IQKENSREALVEPA, corresponding to residues 261-274 of rat NHERF-1, Between the PDZ2 and the ERM binding domains.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

规格

40 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 5% sucrose, 1% BSA

内含物

0.025% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

NHERF1 (Na+/H+ exchanger regulatory factor 1), also known as EBP50 (ezrin, radixin, moesin-binding phosphoprotein 50) is an adaptor protein, which associates with beta-catenin and is required for its localization at the cell-cell junctions, interacts with various G protein-coupled receptors and regulates their traffic, as well as sodium-hydrogen exchange and sodium-dependent phosphate transport. NHERF1/EBP50 inhibits cell motility and is required to suppress anchorage-independent growth. It contains C-terminal ERM (ezrin, radixin, moesin)-binding region and two N-terminal PDZ (postsynaptic-density-95/disc-large/ZO1 homology) domains and is able to form head-to-tail intramolecular conformation to regulate its interactions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cytoskeletal-linking protein; EBP50; ERM-binding phosphoprotein; ezrin-radixin-moesin-binding phosphoprotein 50; NHERF-1; regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3 regulator 1; So; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1

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基因别名: Slc9a3r1

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UniProt ID: (Rat) Q9JJ19

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Entrez Gene ID: (Rat) 59114

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功能
receptor binding protein binding beta-catenin binding gamma-aminobutyric acid transmembrane transporter activity chloride channel regulator activity phosphatase binding protein domain specific binding PDZ domain binding beta-2 adrenergic receptor binding type 2 metabotropic glutamate receptor binding type 3 metabotropic glutamate receptor binding identical protein binding protein anchor ion channel binding macromolecular complex binding myosin II binding dopamine receptor binding binding, bridging growth factor receptor binding channel activator activity
参与通路
renal sodium ion transport plasma membrane organization nuclear migration adenylate cyclase-activating dopamine receptor signaling pathway sensory perception of sound protein localization negative regulation of cell proliferation regulation of cell shape regulation of cell size negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of sodium ion transport gland morphogenesis microvillus assembly actin cytoskeleton organization negative regulation of cell migration cellular phosphate ion homeostasis bile acid secretion glutathione transport positive regulation of ion transmembrane transport cilium organization establishment of epithelial cell apical/basal polarity maintenance of epithelial cell apical/basal polarity regulation of protein kinase activity negative regulation of mitotic cell cycle establishment of Golgi localization negative regulation of protein kinase B signaling gamma-aminobutyric acid import auditory receptor cell stereocilium organization phospholipase C-activating dopamine receptor signaling pathway renal absorption negative regulation of ERK1 and ERK2 cascade protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway cerebrospinal fluid circulation renal phosphate ion absorption import across plasma membrane regulation of renal phosphate excretion negative regulation of cell motility positive regulation of intrinsic apoptotic signaling pathway
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