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This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C3HC type 1; hematopoietic stem/progenitor cell protein 216; nuclear interacting partner of anaplastic lymphoma kinase (ALK); nuclear-interacting partner of ALK; OTTHUMP00000212330; unnamed protein product; zinc finger, C3HC-type 1
基因别名: 1110054L24Rik; HSPC216; NIPA; RGD1561099
UniProt ID: (Human) Q86WB0, (Mouse) Q80YV2
Entrez Gene ID: (Human) 51530, (Mouse) 232679, (Rat) 296957