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Proteintech
NISCH Polyclonal Antibody
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产品信息
13813-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NISCH Fusion Protein Ag4880 (1155-1504 aa encoded by BC038102)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NEELRHLMW SSVVFYQTPG LEVTACVLLS TKAVYFVLHD GLRRYFSEPL QDFWHQKNTD YNNSPFHISQ CFVLKLSDLQ SVNVGLFDQH FRLTGSTPMQ VVTCLTRDSY LTHCFLQHLM VVLSSLERTP SPEPVDKDFY SEFGNKTTGK MENYELIHSS RVKFTYPSEE EIGDLTFTVA QKMAEPEKAP ALSILLYVQA FQVGMPPPGC CRGPLRPKTL LLTSSEIFLL DEDCVHYPLP EFAKEPPQRD RYRLDDGRRV RDLDRVLMGY QTYPQALTLV FDDVQGHDLM GSVTLDHFGE VPGGPARASQ GREVQWQVFV PSAESREKLI SLLARQWEAL CGRELPVELT G (1155-1504 aa encoded by BC038102)
靶标信息
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hIRAS; I-1; I-1 receptor candidate protein; I1R; I1R candidate protein; Imidazoline receptor 1; imidazoline receptor antisera selected; Imidazoline receptor antisera-selected protein; imidazoline receptor I-1; Imidazoline receptor I-1-like protein; Imidazoline-1 receptor; Imidazoline-1 receptor candidate protein; IR1; Nischarin
基因别名: 1200007D05Rik; 3202002H23Rik; AW494485; hIRAS; I-1; IR1; IRAS; KIAA0975; NISCH
UniProt ID: (Human) Q9Y2I1, (Mouse) Q80TM9
Entrez Gene ID: (Human) 11188, (Rat) 306255, (Mouse) 64652
