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Invitrogen
NKCC1 Monoclonal Antibody (6G7D2)
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NKCC1 Antibody (MA5-49260) in IHC (P)
Immunohistochemistry analysis of NKCC1 in paraffin-embedded section of human colorectal adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with NKCC1 Monoclonal antibody (Product # MA5-49260) using a dilution of 5 μg/mL overnight at 4°C. Biotin conjugated goat ant... View More
产品信息
MA5-49260
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
6G7D2
抗原
E.coli-derived human NKCC1/SLC12A2 recombinant protein (Position: K889-K943).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human A549 whole cell, human CACO-2 whole cell, human PC-3 whole cell. IHC: human colorectal adenocarcinoma tissue, mouse colon tissue, rat colon tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
NKCC1 mediates sodium and chloride transport and reabsorption. NKCC1 is a membrane protein and is important in maintaining proper ionic balance and cell volume. NKCC1 is an electrically silent transporter system that mediates sodium and chloride reabsorption. Further, NKCC1 plays a vital role in the regulation of ionic balance and cell volume and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for NKCC1. Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basolateral Na-K-Cl symporter; BSC2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; hNKCC1; mNKCC1; Na-K-2Cl cotransporter 1; protein phosphatase 1, regulatory subunit 141; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Solute carrier family 12 member 2; solute carrier family 12, member 2
基因别名: 9330166H04Rik; BSC; BSC2; mBSC2; NKCC1; PPP1R141; SLC12A2; sy-ns
UniProt ID: (Human) P55011, (Mouse) P55012
Entrez Gene ID: (Human) 6558, (Rat) 83629, (Mouse) 20496
transport
ion transport
potassium ion transport
sodium ion transport
ammonium transport
transepithelial chloride transport
transepithelial ammonium transport
ammonium transmembrane transport
chloride transmembrane transport
chloride transport
hyperosmotic response
gamma-aminobutyric acid signaling pathway
aging
multicellular organism growth
positive regulation of cell volume
detection of mechanical stimulus involved in sensory perception of sound
branching involved in mammary gland duct morphogenesis
mammary duct terminal end bud growth
organic cation transport
transmembrane transport
