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Invitrogen
NMDAR2B Polyclonal Antibody
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产品信息
PA5-143633
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein from the C-terminal region of the NR2B subunit of the rat NMDA receptor.
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 150mM NaCl
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specific for endogenous levels of the ~180 kDa NR2B subunit of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the fusion protein used to generate the antibody. No reactivity towards the NR2A and NR2C subunits.
靶标信息
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer's Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NME2; NR2B; NR3
基因别名: AW490526; EIEE27; GluN2B; GRIN2B; hNR3; MRD6; NMDAR2B; NR2B
UniProt ID: (Human) Q13224, (Mouse) Q01097, (Rat) Q00960
Entrez Gene ID: (Human) 2904, (Mouse) 14812, (Rat) 24410
NMDA glutamate receptor activity
Ras guanyl-nucleotide exchange factor activity
extracellular-glutamate-gated ion channel activity
protein binding
zinc ion binding
glycine binding
receptor activity
ionotropic glutamate receptor activity
receptor binding
interleukin-1 receptor binding
ion channel activity
cation channel activity
calcium channel activity
beta-catenin binding
drug binding
D2 dopamine receptor binding
ionotropic glutamate receptor binding
neurotransmitter binding
metal ion binding
protein heterodimerization activity
cell adhesion molecule binding
transmembrane signal receptor
MAPK cascade
transport
glutamate receptor signaling pathway
chemical synaptic transmission
learning or memory
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
positive regulation of GTPase activity
response to ethanol
ephrin receptor signaling pathway
action potential
behavioral fear response
in utero embryonic development
startle response
suckling behavior
ion transport
cation transport
calcium ion transport
sensory organ development
learning
memory
associative learning
embryo development
regulation of protein kinase A signaling
positive regulation of cell death
positive regulation of glutamate secretion
synaptic transmission, glutamatergic
fear response
receptor clustering
regulation of MAPK cascade
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
behavioral response to pain
rhythmic process
positive regulation of synaptic transmission
detection of mechanical stimulus involved in sensory perception of pain
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane transport
cation transmembrane transport
response to amphetamine
long-term memory
response to mechanical stimulus
response to toxic substance
response to carbohydrate
response to manganese ion
cellular response to magnesium starvation
response to organic cyclic compound
response to amine
hippocampus development
cerebral cortex development
response to magnesium ion
multicellular organismal response to stress
response to cytokine
response to cocaine
response to calcium ion
response to methylmercury
response to electrical stimulus
response to other organism
response to growth hormone
response to fungicide
cellular response to amino acid stimulus
cellular response to manganese ion
cellular response to dsRNA
cellular response to growth factor stimulus
cellular response to lipid
cellular response to organic cyclic compound
