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Invitrogen
NNT1 Polyclonal Antibody
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产品信息
PA5-29935
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human NNT1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: human CLCF1-transfected 293T cells.
Predicted reactivity: Mouse (96%), Rat (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities. Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b) by binding and inducing the tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B cell hyperplasia associated with increases in serum IgG and IgM.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; BSF-3; Cardiotrophin-like cytokine factor 1; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; NNT-1; Novel neurotrophin-1
基因别名: BSF-3; BSF3; CISS2; CLC; CLCF1; NNT-1; NNT1; NR6
UniProt ID: (Human) Q9UBD9
Entrez Gene ID: (Human) 23529
positive regulation of immunoglobulin production
cell surface receptor signaling pathway
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of B cell proliferation
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of neuron apoptotic process
positive regulation of isotype switching to IgE isotypes
positive regulation of astrocyte differentiation
