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NOGO Polyclonal Antibody
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产品信息
OSN00113W-100UL
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Guinea pig
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from human NOGO conjugated to blue carrier protein was used as the antigen
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: NOGO.
靶标信息
Nogo, also known as RTN4, encodes a membrane protein that limits axon growth and regeneration in the central nervous system. The gene produces multiple isoforms (Nogo-A, Nogo-B, Nogo-C) via alternative promoters and splicing; Nogo-A is highly expressed in oligodendrocytes and is the principal inhibitor of neurite outgrowth. Nogo engages receptors including NgR1 (RTN4R), LINGO1, and p75 or TROY, activating RhoA/ROCK signaling that stabilizes growth cone collapse and restricts plasticity after injury. Beyond axon guidance, Nogo isoforms contribute to membrane dynamics, endoplasmic reticulum structure, vascular function, and immune signaling. Experimental blockade of Nogo or its receptor complex can enhance sprouting and functional recovery in animal models, making the pathway a target for therapies in spinal cord injury and stroke.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Foocen; Glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI-220/250; Nogo protein; NSP; Reticulon 4; Reticulon-4; Reticulon-5; RTN-x; Rtn4
基因别名: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; NgA; NI-250; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL; r; rat N; rat NogoA; RTN4; SP1507; Vp20
UniProt ID: (Mouse) Q99P72, (Rat) Q9JK11
Entrez Gene ID: (Mouse) 68585, (Rat) 83765
angiogenesis
nervous system development
axonogenesis
axonal fasciculation
negative regulation of neuron projection development
cerebral cortex radial glia guided migration
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of dopamine secretion
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
negative regulation of axonogenesis
regulation of sensory perception of pain
regulation of nervous system development
cardiac epithelial to mesenchymal transition
negative regulation of neuron projection regeneration
endoplasmic reticulum tubular network organization
regulation of branching morphogenesis of a nerve
aging
response to activity
olfactory nerve development
oligodendrocyte differentiation
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