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Proteintech
NOTCH2/NOTCH2NL Monoclonal Antibody (2D5E1)
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产品信息
68212-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2D5E1
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: PAHALQCRDG YEPCVNEGMC VTYHNGTGYC KCPEGFLGEY CQHRDPCEKN RCQNGGTCVA QAMLGKATCR CASGFTGEDC QYSTSHPCFV SRPCLNGGTC HMLSRDTYEC TCQVGFTGKE CQWTDACLSH PCANGSTCTT VANQFSCKCL TGFTGQKCET DVNECDIPGH CQHGGICLNL PGSYQCQCLQ GFTGQYCDSL YVPCAPSPCV NGGTCRQTGD FTFECNCLPE TVRRGTELWE RDREVWNGKE HDEN
靶标信息
NOTCH2 and NOTCH2NL are members of the Notch receptor family, with NOTCH2 being a transmembrane receptor located on the cell surface. It plays a critical role in cell-to-cell communication during development and tissue homeostasis, affecting cell fate determination, differentiation, proliferation, and apoptosis. NOTCH2 is composed of an extracellular domain with epidermal growth factor-like repeats, a transmembrane domain, and an intracellular domain. On the other hand, NOTCH2NL proteins are also transmembrane proteins that modulate NOTCH2 signaling. They can act as competitive inhibitors or enhancers of NOTCH2 signaling, depending on the specific paralog and cellular context. They are involved in neuronal development and have been linked to human brain evolution, particularly in neocortex expansion. Both NOTCH2 and NOTCH2NL are important players in cellular processes and have structural similarities, but NOTCH2NL proteins have distinct arrangements of domains compared to NOTCH2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2; Notch homolog 2 N-terminal like protein; Notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A
基因别名: AGS2; HJCYS; hN2; N2N; NOTCH2; NOTCH2NL; NOTCH2NLA
UniProt ID: (Human) Q04721, (Human) Q7Z3S9
Entrez Gene ID: (Human) 4853, (Human) 388677
Notch signaling pathway
multicellular organism development
cell differentiation
cell fate determination
marginal zone B cell differentiation
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
apoptotic process
cell cycle arrest
nervous system development
negative regulation of cell proliferation
organ morphogenesis
cell growth
stem cell population maintenance
hemopoiesis
intracellular receptor signaling pathway
tissue regeneration
negative regulation of apoptotic process
positive regulation of Ras protein signal transduction
bone remodeling
regulation of developmental process
atrial septum morphogenesis
Notch signaling involved in heart development
