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Proteintech
NOVA2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
55002-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.21 mg/mL
规格
31.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The antibody is specific to NOVA2.
靶标信息
Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against onconeural disease antigens that are expressed by gynecologic or lung tumors and by neurons. Nova-1 and -2 are both POMA disease antigens. The autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia. Nova-2 is closely related to Nova-1, and is expressed at high levels in neurons during development and at lower levels in the adult lung. In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus. Both Novas are RNA binding proteins, and Nova-2 binds RNA with high affinity and with sequence specificity that differs from Nova-1. They regulate neuronal pre-messenger RNA splicing by directly binding to RNA. Nova-2 target genes function either in the synapse or in axon guidance indicating that Nova-2 is a major regulator of synaptic function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: astrocytic NOVA1-like RNA-binding protein; encodes KH-domain; neuro-oncological ventral antigen 2; neuro-oncological ventral antigen 3; neuronal KH-type RNA-binding protein
基因别名: ANOVA; Gm1424; NEDASB; NOVA-2; NOVA3
UniProt ID: (Human) Q9UNW9, (Mouse) A0A1W2P872
Entrez Gene ID: (Human) 4858, (Mouse) 384569, (Rat) 292681
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