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Invitrogen
NOXA Recombinant Rabbit Monoclonal Antibody (JA30-03)
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产品信息
MA5-32679
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JA30-03
抗原
Synthetic peptide within Human Noxa aa 5-54
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adult T cell leukemia-derived PMA-responsive; Immediate-early-response protein APR; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Protein Noxa
基因别名: APR; NOXA; PMAIP1
UniProt ID: (Human) Q13794
Entrez Gene ID: (Human) 5366
release of cytochrome c from mitochondria
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to UV
response to X-ray
proteasomal protein catabolic process
positive regulation of glucose metabolic process
negative regulation of mitochondrial membrane potential
positive regulation of protein oligomerization
cellular response to glucose starvation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
T cell homeostasis
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to dsRNA
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of neuron apoptotic process
regulation of mitochondrial membrane permeability
negative regulation of fibroblast proliferation
defense response to virus
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hypoxia
intrinsic apoptotic signaling pathway by p53 class mediator
reactive oxygen species metabolic process
positive regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
