Proteintech

NRG1, isoform SMDF Recombinant Rabbit Monoclonal Antibody (240184G2)

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NRG1, isoform SMDF Recombinant Rabbit Monoclonal Antibody (240184G2)

产品信息

83323-6-RR

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1:125-1:500
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:250
-

免疫细胞化学 (ICC/IF)

1:50-1:500
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

240184G2

抗原

NRG1, isoform SMDF fusion protein Ag0803
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG LVGLAVPCCA CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD PIISLDATAA SALWVSSEAY TSPVSRAQSE SEVQVTVQGD KAVVSFEPSA APTPKNRIFA FSFLPSTAPS FPSPTRNPEV RTPKSATQPQ TTETNLQTAP KLSTS

靶标信息

Neuregulin-1 (NRG1) is a gene encoding multiple isoforms involved in various physiological functions, particularly within the nervous system. The SMDF (sensory and motor neuron-derived factor) is one such isoform of NRG1. Located on chromosome 8p12, NRG1 comprises several exons, where alternative splicing gives rise to the diverse isoforms. The SMDF isoform of NRG1 plays a critical role in neural development and the maintenance of neuronal functions, including neurotransmission and synaptic plasticity. This isoform signals through interactions with ErbB family receptors, predominantly ErbB3 and ErbB4, facilitating cellular communication necessary for proper neural function. NRG1, including its SMDF variant, has been implicated in neuropsychiatric conditions such as schizophrenia and bipolar disorder, underscoring its significance in both development and disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1

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基因别名: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297

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Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323

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功能
transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding protein tyrosine kinase activator activity growth factor
参与通路
MAPK cascade activation of MAPK activity cell morphogenesis startle response cardiac conduction system development ventricular trabecula myocardium morphogenesis cell communication activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development locomotory behavior regulation of blood pressure positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling glucose transport peptidyl-tyrosine phosphorylation glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein homodimerization activity regulation of protein heterodimerization activity positive regulation of GTPase activity neurotransmitter receptor metabolic process positive regulation of axon extension negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling neuron fate commitment oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of secretion positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration transmembrane receptor protein tyrosine kinase signaling pathway heart development muscle organ development cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process cell migration cell differentiation positive regulation of cell growth cellular protein complex disassembly regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity animal organ development ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation positive regulation of protein tyrosine kinase activity negative regulation of extrinsic apoptotic signaling pathway in absence of ligand axon ensheathment
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