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Invitrogen
NRG2 Polyclonal Antibody
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NRG2 Antibody (PA5-95030) in WB
Western blot analysis of NRG2 in Lane 1: rat liver tissue lysate (50 µg), Lane 2: COLO320 whole cell lysate (40 µg), Lane 3: SMMC whole cell lysate (40 µg), Lane 4: SW620 whole cell lysate (40 µg). Samples were incubated with NRG2 polyclonal antibody (Product # PA5-95030).
产品信息
PA5-95030
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human NRG2 (289-306aa NGRKNSRLQFNKVKVEDA).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Liver Tissue, COLO320 whole cell, SMMC whole cell, SW620 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Neuregulin 2 is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; NTAK alpha1; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
基因别名: DON1; HRG2; NRG2; NTAK; NTAK_alpha2a
UniProt ID: (Human) O14511, (Rat) O35569
Entrez Gene ID: (Human) 9542, (Rat) 432361, (Mouse) 100042150
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
growth factor activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
epidermal growth factor-activated receptor activity
epidermal growth factor receptor binding
ErbB-3 class receptor binding
growth factor
intercellular signal molecule
MAPK cascade
signal transduction
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
intracellular signal transduction
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
animal organ development
regulation of cell motility
epidermal growth factor receptor signaling pathway
