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Abnova
NTRK3 Polyclonal Antibody, MaxPab™
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产品信息
H00004916-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NTRK3 (NP_001007157.1, 1 a.a. approximately 612 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL NLKDNRDHLV PSTHYIYEEP EVQSGEVSYP RSHGFREIML NPISLPGHSK PLNHGIYVED VNVYFSKGRH GF
靶标信息
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C
基因别名: gp145(trkC); GP145-TrkC; NTRK3; TRKC
UniProt ID: (Human) Q16288
Entrez Gene ID: (Human) 4916
activation of MAPK activity
neuron migration
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
circadian rhythm
positive regulation of cell proliferation
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
modulation by virus of host transcription
positive regulation of cell migration
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
response to ethanol
protein autophosphorylation
ephrin receptor signaling pathway
neuron fate specification
response to axon injury
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
positive regulation of positive chemotaxis
response to corticosterone
positive regulation of synapse assembly
negative regulation of cell death
lens fiber cell differentiation
cellular response to retinoic acid
cochlea development
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
