NeoBiotechnologies

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3/8796)

Name: NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3\/8796)
Brand: NeoBiotechnologies
SKU: 4916-MSM4-P1

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Antibody (4916-MSM4-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human brain stained with NTRK3/TrkC Mouse Monoclonal Antibody (NTRK3/8796). Inset: PBS instead of primary antibody; secondary only negative control.

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Antibody in Western Blot (WB)

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Antibody in SDS-PAGE (SDS-PAGE)

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Immunogen image

Immunogen Image NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) Monoclonal Antibody (NTRK3/8796)

产品信息

4916-MSM4-P1

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2-4 µg/mL

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

NTRK3/8796

抗原

Recombinant fragment (around aa 100-300) of human NTRK3 protein (exact sequence is proprietary).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product cellular localization: Cell surface.

Positive control: Human brain tissue.

Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.

靶标信息

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C

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基因别名: gp145(trkC); GP145-TrkC; NTRK3; TRKC

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UniProt ID: (Human) Q16288, (Rat) Q03351

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Entrez Gene ID: (Human) 4916, (Rat) 29613

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功能

p53 binding GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding neurotrophin binding transmembrane receptor protein tyrosine kinase activity ephrin receptor binding transmembrane signal receptor

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