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Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cytosolic Fe-S cluster assembly factor NUBP1; cytosolic Fe-S cluster assembly factor NUBP1 {ECO:0000255|HAMAP-Rule:MF_03038}; NBP 1; NBP 1 {ECO:0000255|HAMAP-Rule:MF_03038}; NUBP1; nubp1 {ECO:0000312|EMBL:AAH88221.1}; nucleotide binding protein (e.coli MinD like); nucleotide binding protein 1 (E.coli MinD like); nucleotide binding protein 1 (MinD homolog, E. coli); Nucleotide-binding protein 1; nucleotide-binding protein 1 {ECO:0000255|HAMAP-Rule:MF_03038}
基因别名: NBP; NBP1; NBP35; NUBP1
UniProt ID: (Human) P53384, (Mouse) Q9R060, (Rat) Q5I0L4
Entrez Gene ID: (Human) 4682, (Mouse) 26425, (Rat) 287042