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Invitrogen
Nesprin 1 Polyclonal Antibody
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Nesprin 1 Antibody (PA5-115640) in ICC/IF
Immunocytochemistry analysis of Nesprin 1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115640) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat a... View More
产品信息
PA5-115640
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SYNE1(Accession Q8NF91), corresponding to amino acid residues S8670-T8720.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Nesprin 1.
靶标信息
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CPG2 full length; DKFZp781J13156; Enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; Myne-1; Myocyte nuclear envelope protein 1; nesprin 1; Nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; Synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; Syne-1; syne-1 fragment
基因别名: 8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; dJ45H2.2; EDMD4; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; Myne-1; MYNE1; Nesp1; SCAR8; SYNE1
UniProt ID: (Human) H0Y4C0, (Mouse) Q6ZWR6
Entrez Gene ID: (Human) 23345, (Mouse) 64009, (Rat) 499010
nucleus organization
Golgi organization
establishment of nucleus localization
muscle cell differentiation
cytoskeletal anchoring at nuclear membrane
nuclear matrix anchoring at nuclear membrane
positive regulation of receptor-mediated endocytosis
regulation of dendrite morphogenesis
brain development
response to light stimulus
