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Invitrogen
Nkx2.5 Polyclonal Antibody
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图: 1 / 4
Nkx2.5 Antibody (PA5-85768) in IHC (P)
Nkx2.5 Polyclonal Antibody detects Nkx2.5 protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded mouse heart. Green: Nkx2.5 stained by Nkx2.5 Polyclonal Antibody (Product # PA5-85768) diluted at 1:250. Red: beta Actin, a cytoskeleton marker, stained by beta Actin antibody [GT5512] diluted at 1:500. Blue: Fluoroshield with DAPI. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-85768
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of mouse Nkx2.5. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.9 mg/mL
规格
90 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Human (80%), Mouse (100%), Rat (92%), Dog (81%), Bovine (81%).
Positive Control: mouse heart.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac-specific homeobox; Drosophila NK2 transcription factor related, locus 5; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; homeobox protein CSX; homeobox protein NK-2 homolog E; NK2 transcription factor related, locus 5; Nkx-25; rNKx-2.5; unnamed protein product
基因别名: Csx; Nkx-2.5; Nkx2.5; tinman
UniProt ID: (Mouse) P42582, (Rat) O35767
Entrez Gene ID: (Mouse) 18091, (Rat) 114109
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
heart looping
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
atrioventricular node development
bundle of His development
Purkinje myocyte differentiation
cardiac ventricle morphogenesis
cardiac ventricle formation
right ventricular cardiac muscle tissue morphogenesis
ventricular trabecula myocardium morphogenesis
atrial cardiac muscle tissue development
apoptotic process involved in heart morphogenesis
septum secundum development
proepicardium development
pulmonary myocardium development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
endoderm development
heart development
adult heart development
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
positive regulation of sodium ion transport
negative regulation of myotube differentiation
hemopoiesis
cell differentiation
thyroid gland development
embryonic heart tube development
negative regulation of apoptotic process
tongue development
positive regulation of neuron differentiation
positive regulation of heart contraction
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
cardiac muscle tissue development
positive regulation of cardioblast differentiation
ventricular cardiac myofibril assembly
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
cardiac muscle cell development
atrial cardiac muscle cell development
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
pharyngeal system development
cardiac muscle cell proliferation
regulation of cardiac muscle cell proliferation
heart contraction
cardiac muscle contraction
positive regulation of transcription initiation from RNA polymerase II promoter
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
atrioventricular node cell development
atrioventricular node cell fate commitment
embryonic heart tube left/right pattern formation
negative regulation of canonical Wnt signaling pathway
regulation of cardiac conduction
response to estradiol
cellular response to hydrogen peroxide
cellular response to growth factor stimulus
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