Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
ONECUT1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
25137-1-AP
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ONECUT1 Fusion Protein Ag18250 (167-292 aa encoded by BC140830)
偶联物
形式
Liquid
浓度
0.43 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: PYHKDVAGM GQSLSPLSSS GLGSIHNSQQ GLPHYAHPGA AMPTDKMLTP NGFEAHHPAM LGRHGEQHLT PTSAGMVPIN GLPPHHPHAH LNAQGHGQLL GTAREPNPSV TGAQVSNGSN SGQMEEI (167-292 aa encoded by BC140830 )
靶标信息
Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hepatic nuclear factor 6; Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-3/forkhead homolog 12; HNF-6; One cut domain family member 1; One cut homeobox 1
基因别名: D9Ertd423e; Hfh12; HNF-6; HNF6; HNF6A; Hnf6b; OC-1; Oc1; ONECUT1
UniProt ID: (Human) Q9UBC0, (Mouse) O08755
Entrez Gene ID: (Human) 3175, (Mouse) 15379
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
homeodomain transcription factor
liver development
regulation of cell-matrix adhesion
epithelial cell development
glucose metabolic process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
endoderm development
cell differentiation
B cell differentiation
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
endocrine pancreas development
cilium assembly
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
spleen development
system development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
anatomical structure morphogenesis
pancreas development
