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Invitrogen
OTX2 Polyclonal Antibody
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图: 1 / 4
OTX2 Antibody (PA5-39887) in ICC/IF
Immunocytochemistry analysis of OTX2 in immersion fixed NTera‚2 human testicular embryonic carcinoma cell line. Samples were incubated in OTX2 polyclonal antibody (Product # PA5-39887) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow, upper panel) and counterstained with DAPI (blue, lower panel).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-39887
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant human Otx2, corresponding to Met1-Leu289
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 10% cross-reactivity with recombinant human OTX1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. It has two known alternative splice variants with distinct isoforms though presence of other isoforms cannot be excluded. The protein is an early marker of endodermal differentiation of embryonic stem cells and may play a role in the development of the brain and the sensory organs. The protein may bind to BCD target sequence (BTS): 5-'TCTAATCCC-3'. Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: nuclear protein; orthodenticle homolog 2; OTX; unnamed protein product
基因别名: CPHD6; MCOPS5
UniProt ID: (Human) P32243
Entrez Gene ID: (Human) 5015
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
eukaryotic initiation factor 4E binding
sequence-specific double-stranded DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
axon guidance
regulation of smoothened signaling pathway
forebrain development
midbrain development
positive regulation of embryonic development
regulation of fibroblast growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein-containing complex assembly
dopaminergic neuron differentiation
primitive streak formation
positive regulation of gastrulation
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