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Invitrogen
Oncostatin M Polyclonal Antibody
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产品信息
PA5-79773
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M (181-198aa ASDAFQRKLEGCRFLHGY).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: A549 whole cell, A549 whole cell, HELA whole cell. IHC: Human Intestinal Cancer Tissue.
靶标信息
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
positive regulation of acute inflammatory response
immune response
multicellular organism development
peripheral nervous system development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to heat
positive regulation of peptidyl-serine phosphorylation
oncostatin-M-mediated signaling pathway
regulation of growth
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
negative regulation of meiotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
negative regulation of hormone secretion
behavioral response to pain
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell division
positive regulation of apoptotic signaling pathway
